The Neuroradiologic Spectrum of Wolfram Syndrome

A 34-year-old woman developed type 1 diabetes at age 9. Around age 16, she experienced progressive vision loss, followed by gradual sensorineural hearing loss at 24. Genetic testing revealed a WFS1 mutation, confirming Wolfram syndrome (WS), a rare autosomal recessive, progressive neurodegenerative disorder.WS is characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness-summarized by the acronym DIDMOAD.