Inositol-requiring enzyme 1 alpha is essential for dentinogenesis
These findings underscore the essential role of IRE1α in odontoblast function and dentinogenesis. Moreover, they reveal a context-dependent pathogenic role of IRE1α, providing new insights into ER stress in dental tissue development and disease.
Authors
- Tian Liang (ORCID: https://orcid.org/0000-0002-3429-7821)
- Takao Iwawaki (ORCID: https://orcid.org/0000-0001-8753-1979)
- Hua Zhang (ORCID: https://orcid.org/0000-0002-6789-9343)
- Yongbo Lu (ORCID: https://orcid.org/0000-0003-3692-1736)
- Julie Hollien (ORCID: https://orcid.org/0000-0003-0649-1261)
- Qian Xu (ORCID: https://orcid.org/0000-0001-6160-8990)
- Shuzhen Wang (ORCID: https://orcid.org/0000-0003-3869-2463)
- Chunlin Qin (ORCID: https://orcid.org/0000-0002-2906-9074)
- Jiahe Li
Institutions
- Kanazawa Medical University (JP)
- University of Utah (US)
- University of Michigan (US)
- University of Rochester (US)
- Texas A&M University (US)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fphys.2025.1722417
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00