Spinal infection caused by Aspergillus terreus in immunocompetent individuals: a case report and literature review

Spinal infections, particularly those caused by <i>Aspergillus terreus</i>, represent complex and rare clinical challenges. They are even less common in patients with a normal immune system. This case report details the complex diagnosis and treatment process of a 52-year-old female with <i>A. terreus-</i>induced spinal infection. Diagnosis was initially delayed due to non-specific clinical manifestations and ambiguous imaging findings. After treatment with voriconazole (a targeted antifungal agent), the patient's clinical symptoms and imaging indicators improved significantly-this fully demonstrates the effectiveness of voriconazole in treating such specific fungal spinal infections. This case highlights that fungal infection should be considered in immunocompetent patients with suspected spinal infection, and emphasizes the importance of timely diagnosis and individualized targeted antifungal therapy.

Authors

Institutions

Publication Details

Journal
Frontiers in Medicine
Published
2025-12-08
DOI
https://doi.org/10.3389/fmed.2025.1701261
Primary Topic
Antifungal resistance and susceptibility
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Spinal infection caused by Aspergillus terreus in immunocompetent individuals: a case report and literature review

Xiaodong Zhang, Lingyue Meng, Jun Bao Zheng, Yijie Ma et al.
Frontiers in Medicine
Antifungal resistance and susceptibility
article

Spinal infection caused by Aspergillus terreus in immunocompetent individuals: a case report and literature review

Xiaodong Zhang, Lingyue Meng, Jun Bao Zheng, Yijie Ma, Minyu Pei, Lingling Liu, Shuai Guo, Haolin Sun, Xu Guo, Xueyuan Su
article en

Abstract

Spinal infections, particularly those caused by <i>Aspergillus terreus</i>, represent complex and rare clinical challenges. They are even less common in patients with a normal immune system. This case report details the complex diagnosis and treatment process of a 52-year-old female with <i>A. terreus-</i>induced spinal infection. Diagnosis was initially delayed due to non-specific clinical manifestations and ambiguous imaging findings. After treatment with voriconazole (a targeted antifungal agent), the patient's clinical symptoms and imaging indicators improved significantly-this fully demonstrates the effectiveness of voriconazole in treating such specific fungal spinal infections. This case highlights that fungal infection should be considered in immunocompetent patients with suspected spinal infection, and emphasizes the importance of timely diagnosis and individualized targeted antifungal therapy.

Frontiers in MedicineVol. 12
Shanxi Medical University (CN), Peking University (CN), Peking University First Hospital (CN), Taiyuan Central Hospital (CN), Shanxi Fenyang Hospital (CN)
Peking University First Hospital, Peking University
Openalex Percentile: Top 55%
Antifungal resistance and susceptibility
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.