Rapid postoperative platelet decline in a lung adenocarcinoma with sarcomatoid differentiation and concomitant JAK2 V617F mutation: a case report

This case represents a rare coexistence of JAK2 V617F, MET, and TP53 mutations in lung adenocarcinoma. A marked postoperative decline in platelet count was observed without adjuvant therapy, suggesting a possible tumor-associated reactive thrombocytosis rather than a primary hematologic disorder. Recognition of such platelet dynamics may aid in the clinical assessment and follow-up of lung cancer patients.