Comparative evaluation of artificial saliva and complete artificial saliva as solvent vehicles for in vitro toxicity testing of oral tobacco products
These findings emphasize the importance of evaluating additional biological responses alongside cytotoxicity in vehicle control studies. CAS and ORL-300-FT were chosen for future testing due to their minimal vehicle effects and greater biological relevance, providing a robust platform for assessing oral tobacco product toxicity.
Authors
- J. Oldach
- Martin Gutierrez (ORCID: https://orcid.org/0000-0003-3156-3159)
- J. Molignano
- Mariana T. Farcas (ORCID: https://orcid.org/0000-0003-2404-9434)
- Xuefei Cao (ORCID: https://orcid.org/0000-0001-5495-2806)
- Abaigeal B Ritzenthaler
- Yevgeniya V. Prepelitskaya
Institutions
- MatTek Corporation (United States) (US)
- Altria (United States) (US)
- Ashland (United States) (US)
Publication Details
- Journal
- Frontiers in Toxicology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/ftox.2025.1657073
- Primary Topic
- Advanced Drug Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00