CD58 reshapes the immunosuppressive microenvironment in gliomas through PD-L1 upregulation
CD58 drives glioma progression by upregulating PD-L1 and reshaping the tumor microenvironment toward immunosuppression. It serves as an independent prognostic biomarker and a potential therapeutic target. Targeting the CD58-PD-L1 axis may enhance immunotherapy efficacy in gliomas.
Authors
- Wencai Zuo (ORCID: https://orcid.org/0009-0002-7751-837X)
- Siqi Gou
- Lei Zong (ORCID: https://orcid.org/0000-0002-3044-4476)
- Juanhong Wang
- Wei Wei (ORCID: https://orcid.org/0000-0002-6244-3187)
- Wei Liu (ORCID: https://orcid.org/0000-0003-3800-6400)
- Daihua Yu
- Pengfei Zhao (ORCID: https://orcid.org/0000-0001-7300-1571)
Institutions
- Northwest University (CN)
- Affiliated Hospital of Hebei University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fonc.2025.1658467
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00