SCPEP1+ basal cells are associated with the remodeling of oxidative stress signaling networks in idiopathic pulmonary fibrosis
Our multi-omics integration revealed SCPEP1<sup>+</sup> basal cells as central oxidative stress responders and communication hubs in IPF. These findings provide insights into ROS-driven epithelial remodeling and highlight SCPEP1 as a potential contributor to disease-associated pathways that warrants further exploration for its diagnostic or therapeutic relevance.
Authors
- Linyou Zhang (ORCID: https://orcid.org/0000-0002-9946-4213)
- Jiaxin Shi (ORCID: https://orcid.org/0009-0006-9644-5072)
- Simiao Chen (ORCID: https://orcid.org/0000-0003-0555-2157)
- Xiang Zhou (ORCID: https://orcid.org/0000-0002-9344-3294)
- Jing Chen (ORCID: https://orcid.org/0000-0002-9183-8698)
- Ran Xu (ORCID: https://orcid.org/0000-0003-1387-6696)
- Jiaying Zhao (ORCID: https://orcid.org/0000-0002-6009-0568)
- Bo Peng (ORCID: https://orcid.org/0000-0002-1915-0549)
- Meifeng Li (ORCID: https://orcid.org/0000-0003-3161-3611)
- Xiaoyan Chang
- Yupeng Zhao (ORCID: https://orcid.org/0000-0001-7999-8018)
- Tong Lu
- Chengyu Xu
- Chenghao Wang (ORCID: https://orcid.org/0000-0002-2024-8156)
Institutions
- Harbin Medical University (CN)
- Ruijin Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1676086
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00