Spatial microbiome-metabolic crosstalk drives CD8+ T-cell exhaustion through the butyrate-HDAC axis in colorectal cancer
Our study unveils a spatially defined, microbiome-driven metabolic niche that epigenetically programs CD8<sup>+</sup> T-cell exhaustion via the butyrate-HDAC axis, revealing a targetable mechanism to overcome immunotherapy resistance in CRC.
Authors
- Yinxu Zhang
- Yuxi Wang (ORCID: https://orcid.org/0000-0002-4056-5829)
- Xiaomei Liu (ORCID: https://orcid.org/0000-0003-0934-7249)
- Guangyu Zhang (ORCID: https://orcid.org/0000-0002-1242-4391)
- Xiaoyang Chen (ORCID: https://orcid.org/0000-0002-7356-8129)
- Dai Wang (ORCID: https://orcid.org/0000-0003-2281-8586)
- Zhijun Huang (ORCID: https://orcid.org/0000-0002-5534-7576)
- L Z Dou (ORCID: https://orcid.org/0009-0005-8543-0089)
Institutions
- First Affiliated Hospital of Liaoning Medical University (CN)
- Huashan Hospital (CN)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fmicb.2025.1704491
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09