WNT16 from decidual stromal cells orchestrates M2 macrophage polarization via β-catenin signaling and chromatin remodeling at the maternal-fetal interface
DSC-derived WNT16 promotes M2 polarization in decidual macrophages, which involves the activation of the WNT/β-catenin pathway and the feedback of a MYC-DIXDC1 regulatory axis. Our findings reveal an essential immunoregulatory and epigenetic mechanism critical for successful pregnancy.
Authors
- Xi Xue (ORCID: https://orcid.org/0000-0001-5621-1681)
- Jiajia Chen (ORCID: https://orcid.org/0000-0002-9021-8825)
- Jiani Guo (ORCID: https://orcid.org/0000-0002-9899-0924)
- Lingyu Chang
- Meirong Du (ORCID: https://orcid.org/0000-0002-5307-6784)
- Xinyi Li (ORCID: https://orcid.org/0000-0003-4370-9231)
- Xiaoli Sun
- Yan Yang (ORCID: https://orcid.org/0000-0001-7167-0261)
- Weijie Zhao (ORCID: https://orcid.org/0000-0002-3341-9620)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Shanghai First Maternity and Infant Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1712898
- Citations
- 1
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China