Case Report: Successful management of high-volume paclitaxel extravasation with hyaluronidase and dry warm compresses
Based on our literature search, this appears to be the first documented case of high-volume paclitaxel extravasation successfully managed with both hyaluronidase and dry warmth. The intervention proved to be effective in preventing severe local tissue injury, although it did not mitigate neurotoxic effects. Further research is needed to establish standardized management protocols.
Authors
- Maroš Kunderlík
- Bela Mriňáková (ORCID: https://orcid.org/0000-0001-9795-0640)
- Boris Dudík (ORCID: https://orcid.org/0000-0003-0442-8656)
- Ján Klimas (ORCID: https://orcid.org/0000-0002-6845-2105)
- Zuzana Lukačová (ORCID: https://orcid.org/0000-0002-3023-4276)
- Vanda Ušáková
Institutions
- St. Elisabeth Hospital (CW)
- Vysoká Škola Zdravotníctva a Sociálnej Práce sv. Alžbety (SK)
- Comenius University Bratislava (SK)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fonc.2025.1699608
- Primary Topic
- Chemotherapy-related skin toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00