Adipose tissue metabolomics identifies disease stage and tumour invasiveness of rectal cancer
Our study highlights significant metabolic alterations in adipose tissue associated with rectal cancer progression. VAT metabolism reflects tumour invasiveness, while SAT is more indicative of disease stage. Propanoate metabolism may serve as a biomarker for advanced invasion, offering potential for improved staging, reclassification and personalised therapeutic strategies.
Authors
- José Ignacio Rodríguez‐Hermosa (ORCID: https://orcid.org/0000-0002-7183-8308)
- Pere Planellas (ORCID: https://orcid.org/0000-0003-2799-3105)
- Lídia Cornejo (ORCID: https://orcid.org/0000-0001-8158-6418)
- Irma Ramos‐Oliver (ORCID: https://orcid.org/0000-0002-2320-9902)
- R Coll
- Jordi Mayneris‐Perxachs (ORCID: https://orcid.org/0000-0003-3788-3815)
- José Manuel Fernández‐Real (ORCID: https://orcid.org/0000-0002-7442-9323)
- Laura Gallardo‐Nuell
- Antoni Codina‐Cazador
- Anna Pigem Rodeja
- Olga Delisau‐Puig
- Eloi Maldonado‐Marcos
Institutions
- Universitat de Girona (ES)
- Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (ES)
- Clínica Girona (ES)
- Institut d'Investigació Biomèdica de Girona (ES)
- Hospital Universitari de Girona Doctor Josep Trueta (ES)
Publication Details
- Journal
- European Journal of Clinical Investigation
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1111/eci.70157
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81