Fibroblast‐driven MMP‐9/TIMP‐1 imbalance in bronchoalveolar lavage reflects fibrotic progression in interstitial lung disease
Fibroblast-driven MMP-9/TIMP-1 imbalance in BAL reflects fibrotic severity in ILD. The MMP-9/TIMP-1 ratio may represent a supportive biomarker for differential diagnosis and phenotyping of ILD, warranting validation in larger multicenter studies.
Authors
- Maria Bertolotto (ORCID: https://orcid.org/0000-0002-4889-8046)
- Emanuela Barisione (ORCID: https://orcid.org/0000-0001-5365-134X)
- Luca Valle
- Elisabetta Tedone
- Roberto Fiocca (ORCID: https://orcid.org/0000-0002-8856-6185)
- Paolo Giannoni (ORCID: https://orcid.org/0000-0002-7206-376X)
- Fabrizio Montecucco (ORCID: https://orcid.org/0000-0003-0823-8729)
- Daniela de Totero (ORCID: https://orcid.org/0000-0002-8481-7848)
- Marco Grosso (ORCID: https://orcid.org/0000-0002-7083-0929)
- Federico Carbone (ORCID: https://orcid.org/0000-0003-2957-4078)
- Ennio Nano (ORCID: https://orcid.org/0009-0003-1479-8121)
- Simona Pigozzi (ORCID: https://orcid.org/0000-0001-5339-0629)
- Daniela Verzola (ORCID: https://orcid.org/0000-0002-2790-5876)
- Margherita Moriero (ORCID: https://orcid.org/0009-0003-2333-5719)
Institutions
- Ospedale Policlinico San Martino (IT)
- University of Genoa (IT)
Publication Details
- Journal
- European Journal of Clinical Investigation
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1111/eci.70162
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00