USP18 confers protection against allergic asthma by suppressing CCL8 production in alveolar type II epithelial cells
Overall, these findings reveal a previously unrecognized role for USP18 in regulating CCL8 production during asthma progression, highlighting USP18 and CCL8 as potential therapeutic targets for asthma treatment.
Authors
- Ying Lin (ORCID: https://orcid.org/0000-0002-3876-5653)
- Ran Wei (ORCID: https://orcid.org/0000-0002-5121-3650)
- Zhiqing Cai (ORCID: https://orcid.org/0000-0002-7935-2345)
- Wenjun Mao (ORCID: https://orcid.org/0000-0002-4644-9749)
- Xiaoke Liu (ORCID: https://orcid.org/0000-0001-5661-8174)
- Jinhui Cai (ORCID: https://orcid.org/0000-0002-7624-5499)
- Pinglin Lai (ORCID: https://orcid.org/0000-0002-5789-3896)
- Wuju Zhang (ORCID: https://orcid.org/0000-0001-8500-5377)
- Zehui Yao (ORCID: https://orcid.org/0000-0002-7590-1239)
- Ya-Hai Shu (ORCID: https://orcid.org/0000-0003-0971-0431)
- Hong Wang (ORCID: https://orcid.org/0000-0003-2790-6374)
- Sheng Zhang (ORCID: https://orcid.org/0000-0003-0065-8569)
- Zhimin Zhang (ORCID: https://orcid.org/0000-0002-5088-5869)
- Yuxin Wang (ORCID: https://orcid.org/0000-0002-4490-3995)
- Xiaochun Bai (ORCID: https://orcid.org/0000-0001-9631-4781)
- Zhi Rao (ORCID: https://orcid.org/0009-0002-1170-4639)
- Wenping Chen (ORCID: https://orcid.org/0000-0003-2673-1111)
- Huihui Zhang (ORCID: https://orcid.org/0000-0002-7396-2249)
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Sciences (CN)
- Guangzhou Institutes of Biomedicine and Health (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Wuxi People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s12931-025-03433-0
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00