Protective effects of quercetin, the key component of Zuo Gui Wan, against Alzheimer’s disease via the PI3K/AKT pathway: insights from network pharmacology, molecular docking, and cell experiments
Quercetin, the key active ingredient of Zuo Gui Wan, exerts its protective effects against Alzheimer's disease by regulating the PI3K/AKT signaling pathway, inhibiting neuronal cell damage and apoptosis.
Authors
- Yunwei Lu
- G Li
- Jin Zhu (ORCID: https://orcid.org/0000-0003-0235-5465)
- Xiaoli Qin (ORCID: https://orcid.org/0000-0001-6404-4836)
- Lihua Huang (ORCID: https://orcid.org/0000-0002-8943-8038)
- Peize Li
Institutions
- Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Zhejiang University (Medical Sciences)
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3724/zdxbyxb-2025-0661
- Primary Topic
- Bioactive Compounds in Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Zhejiang University
- Basic and Applied Basic Research Foundation of Guangdong Province