High-dose carbidopa achieves sustained levodopa pharmacokinetics and efficacy in Parkinson’s disease models
High-dose carbidopa co-administration is a promising approach to achieve sustained clinical efficacy of levodopa while mitigating the risk of motor complications.
Authors
- Akane Hayashi (ORCID: https://orcid.org/0009-0005-9972-3376)
- Atsushi Hosomi (ORCID: https://orcid.org/0009-0004-2323-6013)
- Junichi Enokizono (ORCID: https://orcid.org/0009-0006-8898-835X)
- Shinichi Uchida (ORCID: https://orcid.org/0009-0009-2704-0065)
Institutions
- Kyowa Kirin (Japan) (JP)
- Kyowa Kirin (France) (FR)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1093/jpp/rgaf118
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00