Sacubitril/Valsartan Attenuates Inflammation and Fibrosis Associated With Decreased Integrin α8 and Inhibits Hepatocarcinogenesis in a Rat Model of Metabolic Dysfunction‐Associated Steatohepatitis
Sac/Val attenuated fibrosis and inflammation in MASH, potentially through suppression of Itga8 expression, oxidative stress, and inflammasome signaling, highlighting Sac/Val as a promising MASH therapy.
Authors
- Xiaying Kuang (ORCID: https://orcid.org/0000-0003-3552-3808)
- Satoru Takahashi (ORCID: https://orcid.org/0000-0002-8139-8158)
- Masayuki Komura (ORCID: https://orcid.org/0009-0005-0000-5009)
- Kei Fujiwara (ORCID: https://orcid.org/0000-0003-4531-4444)
- Akihiro Murakami
- Aya Naiki‐Ito (ORCID: https://orcid.org/0000-0003-0828-2033)
- Yuko Nagayasu
- Hayato Kawamura (ORCID: https://orcid.org/0000-0002-7679-4279)
- Hiroyuki Kato (ORCID: https://orcid.org/0000-0002-5888-6217)
- Kentaro Matsuura (ORCID: https://orcid.org/0009-0005-0163-3971)
- Takanori Suzuki (ORCID: https://orcid.org/0000-0002-8940-2393)
- Hiromi Kataoka
Institutions
- Nagoya City University (JP)
Publication Details
- Journal
- Hepatology Research
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1111/hepr.70086
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00