Endothelial cell-targeting aptamer-empowered exosomes accelerate wound healing by promoting specialized angiogenesis in type 1 diabetic mice
Collectively, our findings emphasize the essential role of specialized angiogenesis in wound repair and propose a novel, advanced EXOs modification-based therapeutic approach to enhance wound healing in both normal and diabetes-related pathophysiological conditions.
Authors
- Yi-Hua Jin
- Ying-Feng Gao
- Li-Hui Bao
- Xinyu Qiu (ORCID: https://orcid.org/0000-0003-0818-4767)
- Hao‐Kun Xu (ORCID: https://orcid.org/0009-0003-7099-3300)
- Bing‐Dong Sui (ORCID: https://orcid.org/0000-0002-7282-0935)
- Chen-Xi Zheng
- Pei Li
- Shengfeng Bai
- Xi Chen (ORCID: https://orcid.org/0000-0001-6974-4321)
- Miao Yu (ORCID: https://orcid.org/0000-0001-7232-8150)
- Jing Lei (ORCID: https://orcid.org/0000-0002-0290-173X)
- Hua Ni (ORCID: https://orcid.org/0000-0001-9137-3707)
- Yi Shuai (ORCID: https://orcid.org/0000-0003-4950-2055)
- Zizhen Guo (ORCID: https://orcid.org/0000-0001-6460-3239)
- Na Zhao (ORCID: https://orcid.org/0000-0003-0329-4246)
- Q. Wang
- Cheng‐Hu Hu (ORCID: https://orcid.org/0000-0003-2443-6485)
Institutions
- Northwestern Polytechnical University (CN)
- Shanghai Jiao Tong University (CN)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Shanghai Ninth People's Hospital (CN)
- Xi'an Honghui Hospital (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xijing Hospital (CN)
- Nanjing University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1186/s13287-025-04846-w
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00