Organoid-derived photoreceptor precursors enriched by CD9⁻CD81mid sorting restore visual function in RCS rats
We established a clinically translatable, non-genetic strategy for enriching human PR precursors using the CD9<sup>-</sup>CD81<sup>mid</sup> marker combination. The enriched cells demonstrate the capacity for photoreceptor differentiation and functional rescue in a preclinical model of retinal degeneration highlighting their potential for cell-based therapy in RDD.
Authors
- Hongling Liu (ORCID: https://orcid.org/0000-0003-1315-1687)
- Yunzhao Fu
- Yuefeng Lv
- Qiyou Li (ORCID: https://orcid.org/0000-0002-9355-2319)
- Yajie Fang (ORCID: https://orcid.org/0000-0003-4119-6305)
- Min Chen (ORCID: https://orcid.org/0000-0002-6625-640X)
- Yong Liu (ORCID: https://orcid.org/0000-0001-7771-4181)
- Bowen Li (ORCID: https://orcid.org/0000-0001-8475-4800)
- Cheng Wang (ORCID: https://orcid.org/0000-0001-5850-4533)
- Xue Zhang (ORCID: https://orcid.org/0000-0002-5782-2174)
- Yuxiao Zeng (ORCID: https://orcid.org/0009-0002-1819-8935)
- Xiangyu He (ORCID: https://orcid.org/0000-0001-5434-4720)
- Y. Bai (ORCID: https://orcid.org/0009-0003-0109-9671)
Institutions
- Army Medical University (CN)
- Southwest Hospital (CN)
- Chongqing University of Technology (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1186/s13287-025-04848-8
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00