Precuneus-to-hippocampus connectivity links LTP-like plasticity to cognitive function in subjective cognitive decline and mild cognitive impairment
This study provides novel evidence that precuneus-to-hippocampus EC mediates the link between synaptic plasticity and cognitive function in SCD and MCI, suggesting the precuneus-hippocampus pathway as a promising target for early diagnosis and intervention.
Authors
- Hanjun Liu (ORCID: https://orcid.org/0000-0003-1466-4193)
- Zhiyong Zhao (ORCID: https://orcid.org/0000-0002-1432-0430)
- Hailang Yan
- Huanping Wang
- Jie Song (ORCID: https://orcid.org/0000-0002-4711-6014)
- Tianjiao Zhang (ORCID: https://orcid.org/0000-0001-9807-8620)
- Qian Lu (ORCID: https://orcid.org/0000-0003-4729-0896)
- Ying Shen (ORCID: https://orcid.org/0000-0001-8541-6010)
- Chuan He
- Shuai Zhang (ORCID: https://orcid.org/0000-0003-3247-5847)
- Yang Han (ORCID: https://orcid.org/0009-0004-6237-5630)
Institutions
- Hong Kong Polytechnic University (HK)
- Sun Yat-sen University (CN)
- Children's Hospital of Zhejiang University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Jiangsu Shengze Hospital (CN)
- Hangzhou Medical College (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- NeuroImage
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.neuroimage.2025.121636
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00