Protective effects of SA-31 in a psychostimulant-induced neurotoxicity model using SH-SY5Y cells
These findings suggest that SA-31 confers neuroprotection by enhancing MS activity, upregulating antioxidant defenses, and improving mitochondrial function. Further studies in rodent models of addiction are planned to evaluate its therapeutic potential for psychostimulant use disorders and related neurodegenerative conditions.
Authors
- Suchismita Acharya
- Ritu A. Shetty
- Charles E. Amankwa (ORCID: https://orcid.org/0000-0002-1120-7053)
- Biddut DebNath
- A. Abraham (ORCID: https://orcid.org/0009-0005-1225-8396)
- Olivia Young (ORCID: https://orcid.org/0000-0003-4518-6059)
- Michael J. Forster (ORCID: https://orcid.org/0000-0002-3284-2558)
- Gondi Sudershan
Institutions
- University of North Texas (US)
- University of North Texas Health Science Center (US)
- Smith-Kettlewell Eye Research Institute (US)
Publication Details
- Journal
- European Journal of Pharmaceutical Sciences
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1016/j.ejps.2025.107399
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00