Cerebellar subregional atrophy in relapsing-remitting multiple sclerosis: Stage-dependent dynamics and pharmacological modulation
This study demonstrated stage-specific patterns of cerebellar atrophy in RRMS and the heterogeneous, stage-dependent effects of DMTs on posterior cerebellar subregions. Lobules IX and VIIIb emerged as critical loci linking pharmacological modulation with cognitive outcomes. These findings suggest that these regions may serve as potential imaging biomarkers of therapeutic response and prognosis in MS.
Authors
- Zhiwei Zhang (ORCID: https://orcid.org/0000-0003-3535-707X)
- Kai Zhang (ORCID: https://orcid.org/0000-0001-6717-4628)
- Bin Yu (ORCID: https://orcid.org/0000-0002-7207-643X)
- Xiaohui Zhang (ORCID: https://orcid.org/0000-0002-4303-7466)
- Yongmei Li (ORCID: https://orcid.org/0000-0001-5558-9738)
- Jinzhou Feng
- Silin Du
- Xiaoya Chen (ORCID: https://orcid.org/0000-0003-0710-9837)
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111679
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00