INHBB promotes liver metastasis of colorectal cancer via regulation of TGF-β/Smad signaling, EMT and anoikis resistance
Our study demonstrates that INHBB drives CRC liver metastasis by upregulating the TGF-β/Smad2/3/Smad4 pathway and anoikis resistance, highlighting its potential as a therapeutic target and prognostic biomarker for metastatic CRC.
Authors
- Jun Zhao (ORCID: https://orcid.org/0000-0001-9890-4582)
- Dafei Dai
- Haibo Jiang
- Haiyuan Zhao (ORCID: https://orcid.org/0000-0001-7495-5940)
- Fubao Liu (ORCID: https://orcid.org/0000-0002-6247-0759)
- Nianzhao Yang
- Jun Liu (ORCID: https://orcid.org/0009-0009-8411-1931)
- Xiaopeng Chen (ORCID: https://orcid.org/0000-0002-3087-5735)
Institutions
- Wannan Medical College (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- Tissue and Cell
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1016/j.tice.2025.103258
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00