Agreement and systematic bias between QuantiFERON chemiluminescent immunoassay and QuantiFERON enzyme-linked immunosorbent assay in the detection of latent tuberculosis infection: A systematic review and meta-analysis
Diasorin's QFT-Plus CLIA and QIAGEN's QFT-Plus ELISA demonstrated substantial overall agreement in detecting LTBI, with the strongest concordance for clearly positive and negative results. Laboratories implementing QFT-Plus CLIA platforms should consider verification studies, and future research should evaluate the clinical significance of discordant results and optimize interpretive algorithms for diverse epidemiologic settings.
Authors
- Felix Bongomin (ORCID: https://orcid.org/0000-0003-4515-8517)
- Ivaan Pitua (ORCID: https://orcid.org/0000-0003-0768-1315)
- Phillip Ssekamatte (ORCID: https://orcid.org/0000-0002-3418-8414)
- Irene Andia Biraro (ORCID: https://orcid.org/0000-0002-8303-6046)
- Diana Sitenda (ORCID: https://orcid.org/0000-0001-8169-2819)
- Bwambale Jonani (ORCID: https://orcid.org/0009-0000-9719-3934)
Institutions
- Gulu University (UG)
- African Bible University (UG)
- Makerere University (UG)
Publication Details
- Journal
- IJID Regions
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1016/j.ijregi.2025.100824
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40