Association between cumulative atherogenic index of plasma and dementia risk score in middle-aged and elderly adults: a longitudinal analysis of the CHARLS cohort

Cumulative elevated CumAIP is independently associated with higher BDRM-estimated dementia risk in Chinese adults (mean age 61.4 ± 8.5 years), with linear and dose-dependent relationships. The association is more prominent in high-risk subgroups: females, aged ≥ 60 years, rural residents, nondrinkers, smokers, and BMI ≥ 24 kg/m². The BDRM's validity supports its reliability. CumAIP's stronger association with dementia risk than LDL-C underscores its value as a comprehensive lipid marker for risk stratification. Dynamic lipid monitoring to maintain low CumAIP may aid dementia prevention in these high-risk groups.