LncRNA AC116914.2 promotes the progression of oral cancer by targeting METTL3 via miR-1245a/ZNF250
This study shows that lncRNA AC116914.2, as a competing endogenous RNA (ceRNA), regulates the expression of METTL3 by competitively binding to miR-1245a with ZNF250, thus promoting OSCC progression. The discovery of this regulatory axis provides new diagnostic markers and therapeutic targets for OSCC.
Authors
- Xinyu Dou
- Zhaolong Dang
- Zihan Jiang (ORCID: https://orcid.org/0000-0003-4336-2928)
- Xiaoshuai Xu (ORCID: https://orcid.org/0000-0003-3012-7216)
- Chunyu Feng (ORCID: https://orcid.org/0000-0002-0268-7526)
- Erhui Jiang
- Z. J. Shang (ORCID: https://orcid.org/0000-0002-4884-8129)
Institutions
- Wuhan University (CN)
- Hubei Provincial Center for Disease Control and Prevention (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1186/s40001-025-03627-8
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00