Cancer prevalence and prognosis among individuals living with HIV and AIDS in Turkey: Multicenter BUHASDER study

BackgroundThis multicentre study evaluated the prevalence, distribution, and risk factors of cancer among people living with HIV (PLWH) in Turkey over two decades. Mortality rates and factors were also investigated.MethodsThis retrospective cohort study included 154 adults diagnosed with cancer and HIV between 2008 and 2024. Data were collected from the medical records. The demographics, clinical characteristics, cancer types, treatments, and outcomes were evaluated. The risk factors for ADCs and mortality were defined using multivariate logistic regression and Cox regression. The estimated survival time was determined using Kaplan-Meier analysis.ResultsAmong 8708 PLWH, cancer prevalence was 1.8% (95% CI:1.5-2). ADCs (66.9%) were twice as frequent as NADCs (33.1%). Most prevalent cancers were non-Hodgkin lymphoma (35.1%), Kaposi sarcoma (29.9%), and lung cancer (7.8%). Age ≤54 years, CD4 + T lymphocyte count ≤94/mm<sup>3</sup>, and HHV-8 co-infection were risk factors for ADCs. Mortality rate was 32%. Non-Hodgkin lymphoma and CD4 + T lymphocyte count ≤232/mm<sup>3</sup> at treatment completion predicted mortality. The 3-years overall survival rate was 67.6%.ConclusionsThis study offers insights into cancer burden among PLWH in Turkey. High rates of ADCs and mortality highlight the importance of early HIV diagnosis and antiretroviral therapy access to reduce cancer burden in this population.

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Publication Details

Journal
International Journal of STD & AIDS
Published
2025-12-07
DOI
https://doi.org/10.1177/09564624251405965
Primary Topic
Viral-associated cancers and disorders
Type
article
Field-Weighted Citation Impact
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article

Cancer prevalence and prognosis among individuals living with HIV and AIDS in Turkey: Multicenter BUHASDER study

Sibel Balcı, Derya Özyiğitoğlu, Sıla Akhan, Derya Öztürk-Engin et al.
International Journal of STD & AIDS
Viral-associated cancers and disorders
article

Cancer prevalence and prognosis among individuals living with HIV and AIDS in Turkey: Multicenter BUHASDER study

Sibel Balcı, Derya Özyiğitoğlu, Sıla Akhan, Derya Öztürk-Engin, Şebnem Çalık, Handan Alay, Şeyma Topal, Melda Türken, Müge Toygar Deniz, Elif Sargın Altunok, Hanife Nur Karakoç, Hülya Özkan Özdemir, Sibel Bölükçü, Oğuz Karabay, Nevin İnce, Ayşe Batırel, Ayşin Kılınç Toker, Özgür Günal, Ahmet Rıza Şahin, Esra Gürbüz, Pınar Ergen, Derya Seyman, Kemalettin Özden, Aybegüm Özşahin, Figen Sarıgül Yıldırım, Elif Aysimi Duman, Şükran Köse, Şafak Kaya, Atahan Çağatay, Selcan Arslan Özel, Özlem Güler, Özlem AYDIN, Özge Çaydaşı, Emre Bayhan
article en

Abstract

BackgroundThis multicentre study evaluated the prevalence, distribution, and risk factors of cancer among people living with HIV (PLWH) in Turkey over two decades. Mortality rates and factors were also investigated.MethodsThis retrospective cohort study included 154 adults diagnosed with cancer and HIV between 2008 and 2024. Data were collected from the medical records. The demographics, clinical characteristics, cancer types, treatments, and outcomes were evaluated. The risk factors for ADCs and mortality were defined using multivariate logistic regression and Cox regression. The estimated survival time was determined using Kaplan-Meier analysis.ResultsAmong 8708 PLWH, cancer prevalence was 1.8% (95% CI:1.5-2). ADCs (66.9%) were twice as frequent as NADCs (33.1%). Most prevalent cancers were non-Hodgkin lymphoma (35.1%), Kaposi sarcoma (29.9%), and lung cancer (7.8%). Age ≤54 years, CD4 + T lymphocyte count ≤94/mm<sup>3</sup>, and HHV-8 co-infection were risk factors for ADCs. Mortality rate was 32%. Non-Hodgkin lymphoma and CD4 + T lymphocyte count ≤232/mm<sup>3</sup> at treatment completion predicted mortality. The 3-years overall survival rate was 67.6%.ConclusionsThis study offers insights into cancer burden among PLWH in Turkey. High rates of ADCs and mortality highlight the importance of early HIV diagnosis and antiretroviral therapy access to reduce cancer burden in this population.

International Journal of STD & AIDSVol. 37(5)
Sakarya University (TR), Izmir University (TR), Recep Tayyip Erdoğan University (TR), Karadeniz Technical University (TR), Dokuz Eylül University (TR), Adıyaman University (TR), Gaziantep Children's Hospital (TR), Antalya Eğitim ve Araştırma Hastanesi (TR), Samsun University (TR), Education Training And Research (US), Kayseri Eğitim ve Araştırma Hastanesi (TR), Sağlık Bilimleri Üniversitesi (TR), Universidad CES (CO), Education and Research Institute (US), Şişli Etfal Eğitim ve Araştırma Hastanesi (TR), Antalya IVF (TR), Gaziantep İslam Bilim ve Teknoloji Üniversitesi, Kocaeli Üniversitesi (TR), Düzce Üniversitesi (TR), Istanbul Medeniyet University (TR), Gaziantep University (TR), Atatürk University (TR), Istanbul University (TR), University of Health Sciences Antigua (AG)
Openalex Percentile: Top 46%
Viral-associated cancers and disorders
DOIOpen Access PDFOpenAlex
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