Evaluation of four chimeric Trypanosoma cruzi recombinant antigens for serological diagnosis of chronic Chagas disease in dogs: a phase II study
The IBMP chimeric antigens demonstrated strong diagnostic performance for detecting T. cruzi infection in dogs, significantly enhancing immunoassay accuracy and minimizing diagnostic failures due to cross-reactivity. The combined use of these antigens represents a promising strategy to further improve sensitivity and specificity in future diagnostic applications.
Authors
- Fred Luciano Neves Santos (ORCID: https://orcid.org/0000-0002-3944-0818)
- Leonardo Maia Leony (ORCID: https://orcid.org/0000-0003-0681-8332)
- Nayara Mendes Louzeiro (ORCID: https://orcid.org/0000-0002-5786-0736)
- Vicente Toscano de Araújo-Neto
- Carlota Josefovicz Belisário (ORCID: https://orcid.org/0000-0003-2772-8475)
- Kamila Gaudêncio da Silva Sales (ORCID: https://orcid.org/0000-0002-7397-5963)
- Ângelo Antônio Oliveira Silva (ORCID: https://orcid.org/0000-0003-1723-6928)
- Thaliane França Costa (ORCID: https://orcid.org/0000-0002-9467-5847)
- Antônia Cláudia Jácome da Câmara (ORCID: https://orcid.org/0000-0001-7337-9320)
- Liléia Diotaiuti (ORCID: https://orcid.org/0000-0002-4976-2618)
- Filipe Dantas‐Torres (ORCID: https://orcid.org/0000-0002-1496-6274)
- Fernanda Lopes Habib (ORCID: https://orcid.org/0000-0001-8246-3954)
- Cláudia Moura de Melo (ORCID: https://orcid.org/0000-0001-9331-003X)
- Natália Erdens Maron Freitas (ORCID: https://orcid.org/0000-0001-6286-1883)
- Natália Dantas Fontes
- Nilson Ivo Tonin Zanchin (ORCID: https://orcid.org/0000-0002-1153-0694)
- Sidilene Pereira Costa
- Andréa Pereira da Costa (ORCID: https://orcid.org/0000-0002-8197-9868)
- Luanna Soares de Melo Evangelista (ORCID: https://orcid.org/0000-0003-1954-2662)
- Paola Alejandra Fiorani Celedón (ORCID: https://orcid.org/0000-0002-1968-7039)
- Deborah Bittencourt Mothé
Institutions
- Universidade Federal do Rio Grande (BR)
- Universidade Federal do Piauí (BR)
- Universidade Federal do Rio Grande do Norte (BR)
- Universidade Tiradentes (BR)
- Instituto de Tecnologia e Pesquisa (BR)
- Universidade Estadual do Maranhão (BR)
- Fundação Carlos Chagas (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1186/s13071-025-07173-4
- Citations
- 1
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 1.35