Lumican from DESC spheroids enhances odontoblastic differentiation of SCAPs
This study illustrates that spheroid culture can restore the epithelial microenvironment of DESCs, leading to the release of Lumican, which targets SCAPs. This research uncovers the crucial roles of Lumican and ITGβ1 in DESCs-SACPs interactions and paves the way for potential therapeutic strategies in dentin regeneration.
Authors
- Jun Sun (ORCID: https://orcid.org/0000-0003-3509-2112)
- Shu-Wei Huang (ORCID: https://orcid.org/0000-0003-1815-6938)
- Hemin Nie (ORCID: https://orcid.org/0000-0002-3657-7333)
- Qin-Yao Zhang (ORCID: https://orcid.org/0000-0003-3348-6265)
- Mingjie Zhang (ORCID: https://orcid.org/0000-0001-9404-0190)
- Lei Lei (ORCID: https://orcid.org/0000-0003-1029-0550)
- Xiaoqian Liu (ORCID: https://orcid.org/0009-0007-0440-7341)
- Mingzhu Liu
Institutions
- Central South University (CN)
- Hunan University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1186/s13287-025-04849-7
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 0.00