Osteopontin induces airway smooth muscle cells proliferation and migration by modulating FAK/Src/YAP axis
Our study indicates that OPN stimulates ASMCs proliferation and migration by binding to α<sub>V</sub>β<sub>3</sub> and activating FAK/Src/YAP axis, suggesting that targeting this pathway might have potential value in the management of airway remodeling of asthma.
Authors
- Guizuo Wang
- Yali Zhao
- Lu Liu (ORCID: https://orcid.org/0000-0003-2683-7215)
- Shu‐Mei Yang
- Jie Du (ORCID: https://orcid.org/0000-0002-8990-1619)
- M Li (ORCID: https://orcid.org/0000-0001-5379-7306)
Institutions
- Shanxi Medical University (CN)
- Shanxi Provincial People’s Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1016/j.intimp.2025.115886
- Citations
- 2
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 2.30