Lactate to hemoglobin ratio predicts short and long term mortality in critically ill patients with Gastrointestinal bleeding

This study investigates the lactate-to-hemoglobin ratio (LHR) as a novel biomarker for predicting short-term and long-term mortality in critically ill patients with gastrointestinal bleeding (GIB). Data from 1387 patients in the MIMIC - IV database were analyzed. Results showed that LHR was significantly associated with 7-day, 28-day and 365-day mortality. It had moderate discriminative ability in predicting mortality, with area under the curve (AUC) values ranging from 0.637 to 0.694. Compared with traditional markers and scoring systems, LHR has certain advantages. However, the study has limitations such as a retrospective design and single - center data. In conclusion, LHR shows promise as a prognostic tool for GIB patients, but further research is needed.

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Publication Details

Journal
Scientific Reports
Published
2025-12-05
DOI
https://doi.org/10.1038/s41598-025-27176-6
Primary Topic
Sepsis Diagnosis and Treatment
Type
article
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article

Lactate to hemoglobin ratio predicts short and long term mortality in critically ill patients with Gastrointestinal bleeding

Ying Xie, Zhenghao Lin, Jia Huang, Fulan Cen et al.
Scientific Reports
Sepsis Diagnosis and Treatment
article

Lactate to hemoglobin ratio predicts short and long term mortality in critically ill patients with Gastrointestinal bleeding

Ying Xie, Zhenghao Lin, Jia Huang, Fulan Cen, Xianjia Ning, Jinghua Wang, Qinglin Wu
article en

Abstract

This study investigates the lactate-to-hemoglobin ratio (LHR) as a novel biomarker for predicting short-term and long-term mortality in critically ill patients with gastrointestinal bleeding (GIB). Data from 1387 patients in the MIMIC - IV database were analyzed. Results showed that LHR was significantly associated with 7-day, 28-day and 365-day mortality. It had moderate discriminative ability in predicting mortality, with area under the curve (AUC) values ranging from 0.637 to 0.694. Compared with traditional markers and scoring systems, LHR has certain advantages. However, the study has limitations such as a retrospective design and single - center data. In conclusion, LHR shows promise as a prognostic tool for GIB patients, but further research is needed.

Scientific ReportsVol. 15(1)
Seoul National University (KR), Longgang Central Hospital (CN), Shenzhen Third People’s Hospital (CN)
Openalex Percentile: Top 50%
Sepsis Diagnosis and Treatment
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Lactate to hemoglobin ratio predicts short and long term mortality in critically ill patients with Gastrointestinal bleeding — Ying Xie, Zhenghao Lin, et al. · Scientific Reports (2025) | TGRS Research Map | TGRS