Exposure to polystyrene nanoparticles induce disruption of mitochondrial homeostasis and impairs trophoblast cell invasion and migration via MDM2/ROCK1 pathway
The study elucidates the intricate connections among mitochondrial dysfunction, autophagy, inflammation, and cell motility in response to PS-NPs, suggesting that targeting the MDM2-ROCK1 pathway could offer a promising approach to alleviate PS-NP-induced toxicity in trophoblast cells and support placental health.
Authors
- Fengchun Gao (ORCID: https://orcid.org/0009-0004-5873-2535)
- Ting Ma (ORCID: https://orcid.org/0000-0002-1100-3472)
- Dongdong Hao (ORCID: https://orcid.org/0000-0002-9692-3007)
- Xiaoping Li (ORCID: https://orcid.org/0000-0002-5057-0226)
Institutions
- Shandong Maternal and Child Health Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1371/journal.pone.0337568
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00