Lime-based supplement reduces calcium oxalate stone recurrence: A multicenter randomized controlled trial
LPR, a lime-based supplement rich in citrate and flavonoids, significantly reduced the 2-year recurrence rate of calcium oxalate stones by approximately 76%. This effect may be mediated by increased urinary citrate excretion, alkalinization, and attenuation of renal inflammation, as evidenced by reduced urinary IL-8 and proteinuria. LPR was well tolerated, with minimal adverse effects, and may serve as a safe, cost-effective adjunct for secondary prevention in patients intolerant to conventional alkali therapy.
Authors
- Supoj Ratchanon (ORCID: https://orcid.org/0009-0001-4389-1400)
- Thasinas Dissayabutra (ORCID: https://orcid.org/0000-0001-7066-0870)
- Pisit Prapunwattana
- Wattanachai Ungjaroenwathana
- Tasanee Klinhom
- Anuthep Burami
- Thosaphol Sasivongsbhakdi
- Weerapat Anegkamol (ORCID: https://orcid.org/0000-0002-9319-4654)
- Ukrit Wayakkanont
- Piyaratana Tosukhowong
- Pisitpol Siriwattana
Institutions
- Burapha University (TH)
- Chulalongkorn University (TH)
- University of Phayao (TH)
- Nopparat Rajathanee Hospital (TH)
- Sappasithiprasong Hospital (TH)
- Sakon Nakhon Rajabhat University (TH)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1371/journal.pone.0336892
- Citations
- 1
- Primary Topic
- Kidney Stones and Urolithiasis Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52