Multimodal mechanisms of di (2-ethylhexyl) phthalate-induced cardiovascular-kidney-metabolic syndrome: Integrating epidemiology, network toxicology and experimental validation
DEHP exposure promotes CKM syndrome through coordinated disruption of metabolic (PPARG), inflammatory (PTGS2), and fibrotic (MMP2) pathways, with obesity serving as a critical effect modifier. The integrated computational and experimental evidence provides a mechanistic basis for future therapeutic interventions.
Authors
- Yue Cao (ORCID: https://orcid.org/0000-0002-2098-7637)
- Xiaohui Huang (ORCID: https://orcid.org/0000-0003-1740-0687)
- Weixing Wen
- Feipeng Qiu
- Jun Li (ORCID: https://orcid.org/0000-0002-1171-7141)
- Hao Zhang (ORCID: https://orcid.org/0000-0001-5624-9217)
- Zhi‐Jie Liu (ORCID: https://orcid.org/0000-0001-7279-2893)
- Lingxiao Li (ORCID: https://orcid.org/0000-0001-5571-5968)
- Yuli Huang (ORCID: https://orcid.org/0000-0001-5104-567X)
Institutions
- The First People's Hospital of Shunde (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.119515
- Citations
- 3
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 3.60