Endoscopic endonasal surgery for prolactin-secreting adenoma: a retrospective multicenter study by the neuroendoscopy section of the Italian Society of Neurosurgery
The EEA is a valid option for the treatment of prolactinomas, with better results for micro tumors and regular macro tumors. This study found that preoperative prolactin values < 184 ng/ml were associated with higher chances of biochemical remission, as was larger pituitary surgery center volume. Currently, the most common surgical indications for prolactinomas are represented by cases that are not responsive or intolerant to DAs. However, interesting future perspectives considering EEA as a possible co-first-line therapy in selected patients have been recently proposed.
Authors
- Filippo Flavio Angileri (ORCID: https://orcid.org/0000-0002-1107-4115)
- Corrado Zenesini
- Viola Bartoletti
- Diego Mazzatenta (ORCID: https://orcid.org/0000-0002-2466-8828)
- Giovanni Lasio (ORCID: https://orcid.org/0000-0003-1068-1674)
- Pier Paolo Mattogno (ORCID: https://orcid.org/0000-0003-2857-9096)
- Stefano Peron (ORCID: https://orcid.org/0000-0002-5449-0338)
- Cesare Zoia (ORCID: https://orcid.org/0000-0001-7304-6120)
- Cosimo Damiano Gianfreda
- Francesco Doglietto (ORCID: https://orcid.org/0000-0002-7438-0734)
- Gianpiero Tamburrini (ORCID: https://orcid.org/0000-0002-8017-4830)
- Roberto Stefini (ORCID: https://orcid.org/0000-0002-9470-3545)
- Luca Massimi (ORCID: https://orcid.org/0000-0003-3088-0822)
- Giannantonio Spena (ORCID: https://orcid.org/0000-0001-6958-3513)
- Elena d’Avella (ORCID: https://orcid.org/0000-0002-9978-0718)
- Mattia Testa
- Angelo Musumeci
- Matteo Zoli (ORCID: https://orcid.org/0000-0001-8838-5408)
- Laura Maria Beatrice Belotti (ORCID: https://orcid.org/0000-0002-5828-6780)
- Maria Pia Tropeano (ORCID: https://orcid.org/0000-0002-4653-1232)
- Simona Serioli (ORCID: https://orcid.org/0000-0001-5155-6736)
- Liverana Lauretti (ORCID: https://orcid.org/0000-0001-7997-1624)
- Martina Cappelletti (ORCID: https://orcid.org/0009-0000-2016-3630)
- Alessandro Fiorindi
- Luigi Maria Cavallo
- Aristide Nanni
- Karl J. Friston
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Messina (IT)
- University of Verona (IT)
- Agostino Gemelli University Polyclinic (IT)
- Surgical Specialties (Canada) (CA)
- Federico II University Hospital (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Surgical Specialties (United States) (US)
- Ca' Foncello Hospital (IT)
- Metropolitana Milanese (Italy) (IT)
- Policlinico San Matteo Fondazione (IT)
- Ospedale Vito Fazzi (IT)
- IRCCS Humanitas Research Hospital (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Journal of neurosurgery
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3171/2025.7.jns242821
- Citations
- 1
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.29