miR-4324-containing extracellular vesicles released in pericardial drainage fluid facilitate post-operative atrial fibrillation
These findings uncover a previously unrecognized high-speed PCF-EVs pathway that propagates proarrhythmic miR-4324 signals from surgical sites to reshape the atrial microenvironment into a pro-arrhythmic milieu via SKP1-TGF-β1/Smad3 axis. PCF, typically discarded, could be repurposed for POAF prophylaxis.
Authors
- Yisi Liu (ORCID: https://orcid.org/0009-0000-7007-7693)
- Taiwei Wang (ORCID: https://orcid.org/0000-0002-6164-9132)
- Yue Gao (ORCID: https://orcid.org/0000-0003-1131-5326)
- Pan Shen (ORCID: https://orcid.org/0000-0001-8529-3727)
- Ying Wu (ORCID: https://orcid.org/0000-0002-3778-8183)
- Shu Ding (ORCID: https://orcid.org/0000-0001-5660-8507)
- Jiamiao Li
- Lin Luo (ORCID: https://orcid.org/0000-0003-3361-2751)
- Jiangang Wang (ORCID: https://orcid.org/0000-0002-3656-2916)
- Yue Sun
- Wei Zhou (ORCID: https://orcid.org/0000-0003-4030-2022)
- Xinyu Wang (ORCID: https://orcid.org/0000-0002-9985-3227)
- Chen Bai
- Gaofu Li
- Chaoyue Gao
- Yongqiang Zhou (ORCID: https://orcid.org/0000-0003-1402-345X)
Institutions
- Qinghai University (CN)
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Beijing Anzhen Hospital (CN)
- Beijing Radiation Center (CN)
- Beijing YouAn Hospital (CN)
- Beijing Chaoyang Emergency Medical Center (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1093/cvr/cvaf239
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81