Ultrasensitive quantification of serum IFN-α and IFN-γ in systemic lupus erythematosus: A cross-sectional observational study
In this study, we observed that IFN-α, but not IFN-γ, significantly associates with inflammation, indices of disease activity and remission, and autoantibody status in SLE. Investigating the potential of IFN-α as a biomarker for treatment response and long-term outcomes is warranted.
Authors
- Elena Heras-Recuero (ORCID: https://orcid.org/0009-0002-7703-3380)
- Iván Ferraz‐Amaro (ORCID: https://orcid.org/0000-0003-0197-5267)
- Miguel Ángel González-Gay (ORCID: https://orcid.org/0000-0002-7924-7406)
- Cristina Almeida-Santiago
- Raquel Largo (ORCID: https://orcid.org/0000-0001-6525-2944)
- Javier Gonzalo Ocejo-Vinyals (ORCID: https://orcid.org/0000-0003-2245-4639)
- Fuensanta Gómez-Bernal (ORCID: https://orcid.org/0000-0002-8597-1943)
- Juan Carlos Quevedo-Abeledo (ORCID: https://orcid.org/0000-0003-0398-9072)
- Luisa María Villar (ORCID: https://orcid.org/0000-0002-9067-3668)
- Beatriz Tejera‐Segura (ORCID: https://orcid.org/0000-0001-5124-8944)
- Arantxa Torres-Roselló (ORCID: https://orcid.org/0000-0002-6881-2035)
- Teresa Blázquez-Sánchez
- Antonia de Vera-González (ORCID: https://orcid.org/0000-0003-3179-6673)
- Enrique García-Barrera (ORCID: https://orcid.org/0009-0002-1026-7318)
Institutions
- Universidad de Cantabria (ES)
- Universidad de La Laguna (ES)
- Hospital Universitario Insular de Gran Canaria (ES)
- Hospital Universitario de Canarias (ES)
- Hospital Universitario de Gran Canaria Doctor Negrín (ES)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Hospital Universitario Ramón y Cajal (ES)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1371/journal.pmed.1004841
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00