Emerging role of transfer RNA-derived small RNAs (tsRNAs) in hepatocellular carcinoma
Although tsRNAs show great promise in HCC diagnosis, prognosis, and therapy, clinical translation remains hindered by gaps in mechanistic understanding, technical challenges in detection, and a lack of large-scale validation. Overcoming these limitations through standardized methodologies and multi-omics integration could unlock their full potential in precision cancer medicine.
Authors
- Mohamed Z. Gad (ORCID: https://orcid.org/0000-0003-1173-8628)
- R.A. Youness (ORCID: https://orcid.org/0000-0001-6268-7942)
- Cédric Coulouarn (ORCID: https://orcid.org/0000-0002-5692-9586)
- Adham H. Mohamed
- Ayman M. Metwally
- Tasneem Abaza (ORCID: https://orcid.org/0000-0002-6787-3784)
- Abdelhamid M. Abdelhamid
- Waleed T. Kotb
Institutions
- Cairo University (EG)
- Misr University for Science and Technology (EG)
- Deutsche Gesellschaft für Internationale Zusammenarbeit (PH)
- Université Paris-Saclay (FR)
- Centre Eugène Marquis (FR)
- Université d'Évry Val-d'Essonne (FR)
- German University in Cairo (EG)
Publication Details
- Journal
- Expert Review of Molecular Diagnostics
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1080/14737159.2025.2600544
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00