Beyond the ordinary: giant ameloblastoma of the jaws - a case series with clinico-radiological features and treatment outcomes

<p><strong>Background:</strong> Giant ameloblastoma is a rare, benign but locally aggressive odontogenic tumor characterized by massive jaw enlargement, accounting for 1% of all jaw tumors, often affecting the mandible. It presents with slow but relentless growth, causing significant facial deformity and functional impairment.</p> <p><br /><strong>Case Presentation:</strong> We report two cases of Giant Ameloblastoma. The first patient reported to the outpatient department an expansile swelling involving the mandible crossing the midline, extending approximately from the right side of the angle to the left side angle. 15.2 cm x 10.5 cm x 11 cm. The second case was reported to the outpatient department, with an expansile swelling involving the right mandible and maxillary region, which was 10 cm x 12cm x 7cm. Both patients had an extraoral draining sinus on the lesion, and both had a previous history of surgery in that region, 20 years back and 11 years back, respectively. The pre-operative investigation included an OPG, CT scan, and haematological parameters. Surgical treatment involved Hemimandibulectomy with adequate margins and microvascular reconstruction with fibular free flap in a single stage.</p> <p><br /><strong>Conclusion:</strong> Tumor histology, anatomical location, and adequacy of tumor resection with safety margins are various factors that influence tumor recurrence and thus must be considered along with the possibility of malignant transformation while formulating a treatment plan for revision cases.</p>