Hydroxychloroquine does not affect endotheliopathy or coagulopathy biomarkers in COVID-19: longitudinal results from the DisCoVeRy randomized trial
HCQ was not found to modify the longitudinal evolution of angiopoietin-2, P-selectin, or D-dimer in hospitalized patients with COVID-19. These findings confirm the absence of vascular benefit, reinforcing evidence against HCQ's clinical utility in COVID-19 and underscoring the need for alternative endothelial-targeted approaches.
Authors
- Clément Massonnaud (ORCID: https://orcid.org/0000-0003-0292-9668)
- David M. Smadja (ORCID: https://orcid.org/0000-0001-7731-9202)
- France Mentré (ORCID: https://orcid.org/0000-0002-7045-1275)
- Jean‐Luc Diehl (ORCID: https://orcid.org/0000-0001-5378-6762)
- Nathan Peiffer‐Smadja (ORCID: https://orcid.org/0000-0003-1166-1958)
- Maya Hites (ORCID: https://orcid.org/0000-0001-6961-6039)
- Florence Ader (ORCID: https://orcid.org/0000-0002-4778-4338)
- Sophie Susen (ORCID: https://orcid.org/0000-0001-5953-163X)
- Aurélien Philippe (ORCID: https://orcid.org/0000-0003-3644-7464)
- Jeanne Rancic
- Annabelle Dupont
- Sophie Luneau
- Christelle Delmas
- Yazdan Yazdanpanah
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Université Libre de Bruxelles (BE)
- Inserm (FR)
- Université Paris Cité (FR)
- Institut Pasteur de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Sorbonne Université (FR)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Centre Hospitalier Universitaire Brugmann (BE)
- Paris Cardiovascular Research Center (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- Centre International de Recherche en Infectiologie (FR)
Publication Details
- Journal
- Angiogenesis
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1007/s10456-025-10023-7
- Citations
- 2
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.79