Whole genome sequencing-based detection of extensively drug-resistant tuberculosis from Ethiopia
Whole-genome sequencing identifies dominant mutations in genes such as gyrA, atpE, and Rv067 that are associated with resistance to second-line anti-tuberculosis drugs. Significant cross-resistance is observed between key second-line drugs, bedaquiline and clofazimine, as well as delamanid and pretomanid. This finding highlights the need for routine genomic surveillance to detect drug resistance early, improve treatment outcomes, and prevent transmission.
Authors
- Yeshiwork Abebaw (ORCID: https://orcid.org/0000-0001-6039-3430)
- Negga Asamene Abera (ORCID: https://orcid.org/0000-0002-1299-1353)
- Saro Abdella Abrahim (ORCID: https://orcid.org/0000-0001-7167-4043)
- Chala Bashea (ORCID: https://orcid.org/0000-0002-5804-2153)
- Ephrem Alemu
- Gemechu Tadesse Leta (ORCID: https://orcid.org/0000-0001-7623-5381)
- Taye Letta
- Mesay Hailu Dangisso (ORCID: https://orcid.org/0000-0003-1245-8839)
- Biniyam Dagne (ORCID: https://orcid.org/0000-0002-5930-2690)
- Getu Diriba (ORCID: https://orcid.org/0000-0002-0166-682X)
- Melak Getu (ORCID: https://orcid.org/0000-0002-7650-0605)
- Getachew Seid (ORCID: https://orcid.org/0000-0002-8708-386X)
- Feyissa Challa Waka (ORCID: https://orcid.org/0000-0002-2624-6661)
- Muluwork Getahun (ORCID: https://orcid.org/0000-0003-3407-983X)
- Amanuel Wondimu
- Abraham Ali (ORCID: https://orcid.org/0000-0002-6762-2678)
- Atsbeha Gebreegziabxier Weldemariam (ORCID: https://orcid.org/0000-0003-1987-6996)
- Zelalem Abate (ORCID: https://orcid.org/0000-0001-6040-9308)
- Michael Hailu
- Getachew Tollera (ORCID: https://orcid.org/0000-0002-5575-8439)
- Andargachew Kumsa
- Abyot Meaza (ORCID: https://orcid.org/0000-0002-8180-1816)
- Ayinalem Alemu (ORCID: https://orcid.org/0000-0001-5307-8774)
- Betselot Zerihun (ORCID: https://orcid.org/0000-0003-4277-2247)
- Atlabachew Liaulseged
- Hilina Mollalign (ORCID: https://orcid.org/0000-0002-1918-0668)
- Tsegaye Getachew (ORCID: https://orcid.org/0000-0002-6614-2445)
Institutions
- Government of Ethiopia (ET)
- Ethiopian Public Health Institute (ET)
- Clinton Health Access Initiative (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1038/s43856-025-01271-1
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79