Characterization of cultivated nasal mucosal epithelial cell sheets for ocular surface reconstruction: an in vitro and in vivo study
Following transplantation, the CUNMEC sheet presented a stratified epithelial layer containing GCs but without cilia and expressed progenitor cell markers, which are morphologically similar to those of ocular surface epithelia and may have the potential to function as a surrogate epithelium for ocular surface reconstruction, especially in dry eye conditions.
Authors
- Jui‐Yang Lai (ORCID: https://orcid.org/0000-0002-9227-8549)
- Shu-Hung Chen
- Shiang‐Fu Huang (ORCID: https://orcid.org/0000-0003-3582-9938)
- Yi‐Jen Hsueh (ORCID: https://orcid.org/0000-0003-3380-7188)
- Yueh-Ju Tsai (ORCID: https://orcid.org/0000-0002-9134-2043)
- Yi-Hua Chen (ORCID: https://orcid.org/0000-0002-9615-9272)
- Yao Lung Chang
- David Hui‐Kang (ORCID: https://orcid.org/0000-0003-1847-8961)
- Yi-Lin Liao
Institutions
- Ming Chi University of Technology (TW)
- Chang Gung University of Science and Technology (TW)
- Chang Gung University (TW)
- National Tsing Hua University (TW)
- Chang Gung Memorial Hospital (TW)
- Xiamen Chang Gung Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1186/s13287-025-04802-8
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00