M-ZIF-67 (M = Cu, Ni, Fe, Zn) derived bimetallic porous polyhedrons for non-enzymatic amperometric glucose detection

Co in the lattice of ZIF-67 can be easily replaced by non-precious metal (Cu, Ni, Fe, Zn) to prepare non-precious metal (Cu, Ni, Fe, Zn) doped ZIF-67, which can be employed as excellent precursors to prepare bimetallic porous polyhedrons. In these bimetallic porous polyhedrons, hybrids containing carbon and nitrogen (C/N hybrids) are the basic framework, and bimetallic oxides are the key catalytic active centers. C/N hybrids possess good biocompatibility, bimetallic oxides own unique bimetallic synergistic catalytic effects, which jointly achieve the non-enzymatic electrochemical sensing for glucose. These bimetallic porous polyhedrons (Cu(2 %)&Co@PCN, Ni(1 %)&Co@PCN, Fe(1 %)&Co@PCN and Zn(1 %)&Co@PCN) not only reveal excellent performance for glucose amperometric detection, but also can be employed to detect glucose in the human serum samples, indicating that they have great commercial value for developing a new generation of non-enzymatic glucose electrochemical sensors.