Quality of Life Over Quantity: Conscious Refusal of Treatment and Stable Course of Gastric Signet-Ring Cell Carcinoma in a 94-Year-Old Woman

We report the case of a 94-year-old woman with histologically confirmed signet-ring cell carcinoma (SRCC) of the stomach (ICD-O-3.2 code 8490/3). The patient consciously declined oncological treatment and received only supportive and symptomatic care. Over a follow-up period of at least 12 months, she has remained alive, active, cognitively intact, and socially engaged. Despite the typically aggressive histological subtype, the disease followed an indolent clinical course. This case highlights the biological heterogeneity of SRCC and the importance of personalised oncogeriatric decision-making that prioritises autonomy and quality of life in the oldest-old population, consistent with contemporary European Society for Medical Oncology (ESMO)/International Society of Geriatric Oncology (SIOG) recommendations and palliative-oriented medical principles.

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Publication Details

Journal
Cureus
Published
2025-12-06
DOI
https://doi.org/10.7759/cureus.98597
Primary Topic
Gastric Cancer Management and Outcomes
Type
article
Field-Weighted Citation Impact
0.00
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article

Quality of Life Over Quantity: Conscious Refusal of Treatment and Stable Course of Gastric Signet-Ring Cell Carcinoma in a 94-Year-Old Woman

А. В. Мартыненко
Cureus
Gastric Cancer Management and Outcomes
article

Quality of Life Over Quantity: Conscious Refusal of Treatment and Stable Course of Gastric Signet-Ring Cell Carcinoma in a 94-Year-Old Woman

А. В. Мартыненко
article en

Abstract

We report the case of a 94-year-old woman with histologically confirmed signet-ring cell carcinoma (SRCC) of the stomach (ICD-O-3.2 code 8490/3). The patient consciously declined oncological treatment and received only supportive and symptomatic care. Over a follow-up period of at least 12 months, she has remained alive, active, cognitively intact, and socially engaged. Despite the typically aggressive histological subtype, the disease followed an indolent clinical course. This case highlights the biological heterogeneity of SRCC and the importance of personalised oncogeriatric decision-making that prioritises autonomy and quality of life in the oldest-old population, consistent with contemporary European Society for Medical Oncology (ESMO)/International Society of Geriatric Oncology (SIOG) recommendations and palliative-oriented medical principles.

CureusVol. 17(12)
Tashkent Pediatric Medical Institute (UZ)
Openalex Percentile: Top 43%
Gastric Cancer Management and Outcomes
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