Hepatic steatosis in postmenopausal women is characterized by distinct serum extracellular vesicle proteomic signatures
This study demonstrates that circulating EV proteomes differ by hepatic steatosis status in postmenopausal women. While exploratory, candidate EV proteins such as INHBE and AFM merit validation as biomarkers and potential contributors to MASLD in this high-risk population.
Authors
- Melissa Martinez (ORCID: https://orcid.org/0000-0003-2285-6136)
- Johanna Kay DiStefano (ORCID: https://orcid.org/0000-0002-3286-0270)
- Carrie Karvonen‐Gutierrez (ORCID: https://orcid.org/0000-0002-1950-5397)
- Ritin Sharma (ORCID: https://orcid.org/0000-0001-8365-9916)
- Michelle M. Hood (ORCID: https://orcid.org/0000-0002-1049-8426)
- Sioḃán D. Harlow (ORCID: https://orcid.org/0000-0002-9899-356X)
- Krystine Garcia‐Mansfield (ORCID: https://orcid.org/0000-0002-9089-2254)
- Maya Willey (ORCID: https://orcid.org/0009-0003-8282-4643)
- Patrick Pirrotte (ORCID: https://orcid.org/0000-0003-1360-6039)
- Ignazio Stefano Piras (ORCID: https://orcid.org/0000-0003-4024-3368)
- Brooke Lovell (ORCID: https://orcid.org/0009-0008-1023-2186)
- Xiumei Wu (ORCID: https://orcid.org/0000-0002-9469-5450)
Institutions
- Translational Genomics Research Institute (US)
- University of Michigan (US)
- City of Hope (US)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1186/s12916-025-04571-4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00