Multitarget inhibitory effects of lemongrass essential oil on Porphyromonas gingivalis: synergistic regulation of heme utilization, biofilm formation, and the metabolic pathway of ferroptosis
LEO demonstrated multitarget inhibitory effects by attenuating P. gingivalis virulence and regulating macrophage oxidative and iron homeostasis. These findings support its potential as a natural adjunctive or preventive agent in periodontitis therapy.
Authors
- Rifat Nowshin Raka (ORCID: https://orcid.org/0000-0002-3337-5605)
- Junsong Xiao (ORCID: https://orcid.org/0000-0001-6778-8187)
- Hua Wu (ORCID: https://orcid.org/0000-0002-9883-4091)
- Yue Yuan (ORCID: https://orcid.org/0000-0003-1887-3523)
- Zhongwei Zhang (ORCID: https://orcid.org/0000-0001-6720-2406)
- Zixuan Liu (ORCID: https://orcid.org/0009-0005-0631-1664)
- Jinlong Sun
Institutions
- Beijing Technology and Business University (CN)
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1186/s12906-025-05210-4
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00