Cyclin B2 facilitates glycolysis and tumor progression in pancreatic ductal adenocarcinoma by promoting histone lactylation
The glycolysis-CCNB2-H3K18la-TTK/BUB1B signaling axis exacerbates the malignant progression of PDAC, providing insights into potential lactylation-based therapeutic strategies for this disease.
Authors
- Xiangjie Li (ORCID: https://orcid.org/0000-0002-9600-8984)
- Xiaolong Liu (ORCID: https://orcid.org/0000-0002-5899-6563)
- Jianming Shi (ORCID: https://orcid.org/0000-0003-0695-5660)
- Bin Ma (ORCID: https://orcid.org/0000-0001-7247-8714)
- Hao Chen (ORCID: https://orcid.org/0000-0003-0018-480X)
- Yuhan Wang (ORCID: https://orcid.org/0009-0006-8868-5316)
- Zhen Ma (ORCID: https://orcid.org/0009-0006-4348-1176)
- Lei Gao (ORCID: https://orcid.org/0000-0002-3897-6362)
- Zhenyu Yin (ORCID: https://orcid.org/0000-0002-1763-8460)
Institutions
- Gansu Provincial Hospital (CN)
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1186/s12885-025-15172-y
- Citations
- 2
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87