Early peripheral blood gene expression predicts 90-day outcomes following subarachnoid hemorrhage
This discovery study demonstrates that a small panel of 20 genes expressed in peripheral blood after SAH has the potential for predicting 90-day outcomes following SAH. It also shows that neutrophils may be important drivers of SAH outcomes and could represent therapeutic targets.
Authors
- Garreck Lenz (ORCID: https://orcid.org/0000-0002-3233-0763)
- Kwan Ng (ORCID: https://orcid.org/0000-0001-7969-9982)
- H. Alex Choi (ORCID: https://orcid.org/0000-0001-7218-832X)
- Frank R. Sharp (ORCID: https://orcid.org/0000-0002-5642-1459)
- Lara Zimmermann
- Jeffrey R. Vitt (ORCID: https://orcid.org/0000-0002-8339-1232)
- Ben Waldau (ORCID: https://orcid.org/0000-0002-8044-0764)
- Nerissa Ko (ORCID: https://orcid.org/0000-0002-3439-0559)
- Aaron M. Gusdon (ORCID: https://orcid.org/0000-0002-3350-6601)
- Bradley P. Ander (ORCID: https://orcid.org/0000-0003-2320-7920)
- Branden Cord (ORCID: https://orcid.org/0000-0002-9120-5989)
- Bodie Knepp (ORCID: https://orcid.org/0000-0002-0761-8060)
- Glen C. Jickling (ORCID: https://orcid.org/0000-0003-3543-0820)
- Boryana Stamova
- Fernando Rodríguez (ORCID: https://orcid.org/0000-0001-7582-482X)
- Ryan C. Martin (ORCID: https://orcid.org/0000-0001-6189-929X)
- Alan Yee (ORCID: https://orcid.org/0000-0002-1180-4827)
- Heather Hull
Institutions
- University of Alberta (CA)
- University of California, San Francisco (US)
- University of Alberta Hospital (CA)
- The University of Texas Health Science Center (US)
- University of California, Davis (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1186/s12974-025-03630-0
- Primary Topic
- Intracranial Aneurysms: Treatment and Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00