Losartan attenuates depression-like behavior in epileptic rats by regulating the TGF-β/Smad signaling
The TGF-β/Smad Signaling is an important Signaling leading to depression-like behavior in epileptic rats. Losartan is a drug that can significantly improve the depression-like behavior of epileptic rats by regulating the TGF-β/Smad Signaling. Findings in this study support losartan as a repurposable central nervous system drug for comorbid depression in epilepsy, warranting further clinical investigation.
Authors
- Junjie Tan (ORCID: https://orcid.org/0000-0002-9983-1562)
- Penghui Cao (ORCID: https://orcid.org/0000-0001-8318-376X)
- Jinwei Wang (ORCID: https://orcid.org/0000-0003-0128-8408)
- Ziyan Fang (ORCID: https://orcid.org/0009-0006-7125-0252)
- Nannan Pan (ORCID: https://orcid.org/0009-0008-7129-0275)
- S H Shen
Institutions
- Sun Yat-sen University (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
- Guangdong Province Women and Children Hospital (CN)
- Guangdong 999 Brain Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.ibneur.2025.12.003
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00