Genomic and structural characterization of a reassortant H9N2 avian influenza virus from a human case
This case illustrates that H9N2 infection can cause severe disease in immunocompromised patients and provides genomic and structural insights into a reassortant H9N2 strain detected in humans. The close similarity of the HA gene sequence between this strain and environmental isolates highlights the importance of continued surveillance of avian influenza viruses.
Authors
- Yiyun Chen (ORCID: https://orcid.org/0000-0002-7442-3239)
- Pengzhe Qin
- Dan Xia
- Pingting Zhu (ORCID: https://orcid.org/0000-0002-1826-2725)
- Jingjing Zhang (ORCID: https://orcid.org/0000-0002-1041-793X)
- Yuan Liu (ORCID: https://orcid.org/0000-0003-4880-5185)
- Weijia Wang (ORCID: https://orcid.org/0000-0001-5293-4065)
- Qing‐Yu He (ORCID: https://orcid.org/0000-0003-0503-9492)
- Yan‐Hui Liu (ORCID: https://orcid.org/0000-0002-3722-3334)
- Lan Cao
- Yifan Pan (ORCID: https://orcid.org/0000-0001-9029-3975)
- Yuqian Wu
- Zhoubin Zhang (ORCID: https://orcid.org/0000-0003-4448-0758)
- Tengfei Zhou
- Xinwei Wu
- Biao Di
Institutions
- Guangzhou Center for Disease Control and Prevention (CN)
- Guangdong Provincial Center for Disease Control and Prevention (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1016/j.ijid.2025.108290
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00