Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia
This study signifies the critical consequences of developmental timing in cancer initiation, revealing that identical driver mutations in fetal- versus postnatal-origin leukemias exhibit fundamentally distinct biology and treatment responses. Recognizing these developmental differences opens avenues for personalized therapeutic strategies, improving outcomes for pediatric patients with aggressive disease subtypes in leukemia.
Authors
- Eric So
- Meghana Sreenath (ORCID: https://orcid.org/0000-0002-5304-1223)
- Jennifer C. Dempsey (ORCID: https://orcid.org/0000-0002-5937-5830)
- Kimberly A. Aldinger (ORCID: https://orcid.org/0000-0002-5406-8911)
- Noelle Wheeler (ORCID: https://orcid.org/0000-0002-9376-7731)
- Julie A. Reisz (ORCID: https://orcid.org/0000-0002-7296-4963)
- Mark Wunderlich (ORCID: https://orcid.org/0000-0002-2166-5146)
- Jerry E. Chipuk (ORCID: https://orcid.org/0000-0002-1337-842X)
- Rhonda E. Ries (ORCID: https://orcid.org/0000-0002-3702-7923)
- Mirela Berisa (ORCID: https://orcid.org/0000-0001-7347-9823)
- Bridget Kelly Marcellino (ORCID: https://orcid.org/0000-0001-8590-6175)
- Levan Mekerishvili (ORCID: https://orcid.org/0000-0002-4792-5356)
- Franco Izzo (ORCID: https://orcid.org/0000-0002-5813-6504)
- Giang T. Pham (ORCID: https://orcid.org/0009-0004-0822-4508)
- Persephone Fiore (ORCID: https://orcid.org/0009-0003-8648-8739)
- Angelo D’Alessandro (ORCID: https://orcid.org/0000-0002-2258-6490)
- Daniel J. Puleston (ORCID: https://orcid.org/0000-0002-8437-0732)
- Zayna Diaz (ORCID: https://orcid.org/0009-0002-5526-9077)
- Dan Filipescu (ORCID: https://orcid.org/0000-0001-6381-2557)
- Soheil Meshinchi (ORCID: https://orcid.org/0000-0002-6276-4423)
- Ian G. Phelps
- Emily Bernstein (ORCID: https://orcid.org/0000-0001-6533-8326)
- Eirini P. Papapetrou (ORCID: https://orcid.org/0000-0001-7002-417X)
- Elvin Wagenblast (ORCID: https://orcid.org/0000-0002-0709-2759)
- Tommaso Balestra (ORCID: https://orcid.org/0000-0002-0225-9724)
- Dan Doherty (ORCID: https://orcid.org/0000-0001-9377-028X)
- Sarah K. Tasian (ORCID: https://orcid.org/0000-0003-1327-1662)
- Miguel Quijada‐Álamo (ORCID: https://orcid.org/0000-0002-4831-4565)
- Nikita Poddar (ORCID: https://orcid.org/0000-0003-3037-5519)
- Saul Carcamo (ORCID: https://orcid.org/0000-0002-1510-1045)
- Shayan Saniei (ORCID: https://orcid.org/0000-0001-9590-400X)
- Ian A. Glass (ORCID: https://orcid.org/0000-0001-6762-8407)
- Christopher M. Sturgeon (ORCID: https://orcid.org/0000-0003-1508-4414)
- Subrina Persaud (ORCID: https://orcid.org/0000-0002-1386-7565)
- Dan A. Landau (ORCID: https://orcid.org/0000-0003-2346-9541)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-6566-6693)
- Zhihong Chen (ORCID: https://orcid.org/0000-0001-7403-7015)
- Mimi Zhang (ORCID: https://orcid.org/0000-0003-3273-540X)
- Dan Hasson (ORCID: https://orcid.org/0000-0001-7943-1636)
- Grace S. Freed (ORCID: https://orcid.org/0000-0002-3360-958X)
- Maria Gracia Gonzalez (ORCID: https://orcid.org/0009-0004-9503-0604)
- Noshin Azra Rahman (ORCID: https://orcid.org/0000-0002-4476-0197)
- C. Chao (ORCID: https://orcid.org/0009-0008-2165-1386)
- Jack H. Peplinski (ORCID: https://orcid.org/0000-0001-5097-0652)
- Isabella G. Martinez (ORCID: https://orcid.org/0000-0002-5372-3873)
- Anna Mei (ORCID: https://orcid.org/0009-0001-9794-8898)
- Ke Wang (ORCID: https://orcid.org/0000-0002-2439-8733)
- Katherine Lachman (ORCID: https://orcid.org/0009-0001-3997-7439)
- Yasmeen Otaibi
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Children's Hospital of Philadelphia (US)
- University of Washington (US)
- Cornell University (US)
- Fred Hutch Cancer Center (US)
- Mount Sinai Medical Center (US)
- Child Health and Development Institute (US)
- New York Genome Center (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Pennsylvania (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1158/2159-8290.cd-25-0556
- Citations
- 1
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 1.88